This KTP project will bring together the collective expertise of Labskin Ltd and Aston University to develop the first immune-competent 3D model of human skin (i.e. skin incorporating immune cells), replacing imperfect animal models and driving exploitation of this innovation for the development of novel therapies, toxicology assays and compound screening.
The key objective of this KTP is to further develop Labskin's existing human skin model by introducing an important immune cell called the macrophage, a crucial cell type that can drive skin repair and avoidance of scarring, but which can also drive disease if inappropriately controlled. Thus, the main area of focus is to develop this novel immune-competent model to allow for the first time an in vitro analysis of human skin and the factors that may control health and disease.
Candidate Profile:
MSc or above in cell biology, immunology. PhD graduates are preferred for their direct experience with immunology and specialised equipment, however MSc or MRes graduates with extensive practical elements to their qualification will also be considered.
Skills/experience required include:
Essential for the role:
- Proficiency in cell culture, ideally using long-term cultures
- Skills in immune assays (e.g. ELISA, antibody staining of cells)
- Excellent aseptic technique
- Independence and strong problem-solving skills
- Strong IT and data analysis abilities
- Ability to quickly adopt new laboratory techniques (supported with training from the academic team)
Desirable for the role:
- Experience in industry, intersectoral projects, or working within developing businesses
- Experience of 3D cell culture models
- Microscopy techniques and an understanding of histology and pathology
- Self-motivated individual who can work with minimal supervision
- Effective time management
- Ability to meet deadlines
- A proactive attitude.
Main responsibilities:
- To define an immune cell culture that integrates with other skin cells to faithfully model human skin in health and disease
- To explore skin immunity, as the model will benefit translational skin research
- To effectively integrate the technically challenging existing cell biology of the current models with the characterised immune cell possibilities that can be incorporated
- To manage your time and budget for the project and ensure high-quality record keeping enabling timely IP protection.
Personal attributes:
- Strong interpersonal skills to successfully work with various stakeholders.
- Strong communication and presentation skills. The ability to work within a cross-disciplinary project team.
- Leadership qualities, professionalism, strong self-organisation, and time management skills to deliver agreed milestones and objectives.
- Highly motivated and adaptable.
- Career focused.
- Ability to work independently, as well as part of the team and use initiative.
- Strong desire to pursue innovative approaches, adopt new technologies and new data processing methods.
Additional Benefits and support:
Career prospects:
60% of our KTP associates are being offered employment by the companies at the end of the KTP.
This is a Knowledge Transfer Partnership (KTP) funded by Labskin and Innovate UK. It is essential you understand how KTP works and the vital role you will play if you secure this position. To learn more please visit: www.aston.ac.uk/ktp
The Company: Labskin is the leading commercially available lab-grown full-thickness human skin model that naturally supports the skin’s microbiome. Web page: https://labskin.co.uk/index.php/contact-us/
Aston University: You will work in a project team with Professor Andrew Devitt and Dr Ivana Milic from Aston University and the Senior Management Team at Labskin, with the support of the IUK’s Knowledge Transfer Adviser.
Location: You will be based at Labskin, York, but will have access to facilities at Aston University in central Birmingham. Some travel to Aston University and key clients may also be required. Flexible working can be arranged.
For informal enquiries about this role please e-mail Andrew Devitt: a.devitt1@aston.ac.uk
If you think this isn’t the right opportunity for you, please explore other KTP vacancies across the country: https://www.ktp-uk.org/jobs/
This role is likely to qualify for endorsement under the Endorsed Funder route of the Global Talent visa. This visa is for talented or promising individuals in academia or research in fields such as science, engineering, medicine, social sciences, or humanities.
See the Home Office guidance: https://www.gov.uk/global-talent
It is an Innovate UK requirement that candidates hold a visa or immigration permission to cover the full duration of the contract. The successful candidate is therefore expected to apply for a visa as necessary in line with their contract duration.
The University celebrates the rights of freedom of speech and academic freedom and is committed to maintaining and protecting these rights within the law. An offer to work at Aston University will never be denied on the basis of an individual’s lawful expression of their beliefs, ideas or opinions.
Aston University is an equal opportunities employer and welcomes applications from all sections of the community. It promotes equality and diversity in all aspects of its work. We strive to have robust inclusivity strategies in place, to encourage colleagues to have the confidence and freedom to be themselves in the workplace. For more information, visit: https://www2.aston.ac.uk/about/inclusive-aston
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